Concepedia

Accelerating reaction modeling using dynamic flow experiments, part 2: development of a digital twin

Klara Silber, Peter Sagmeister, Christine Schiller, Jason D. Williams, Christopher A. Hone, C. Oliver Kappe

Reaction Chemistry & Engineering · 2023 · 20 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

We describe the development of a digital twin for a Michael addition continuous-flow process using data generated from dynamic flow experimentation.

References

25

Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

Sau L. Lee, Thomas O’Connor, Xiaochuan Yang et al. · Journal of Pharmaceutical Innovation · 2015 · 853 citations · Full text

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The rise of self-driving labs in chemical and materials sciences

Milad Abolhasani, Eugenia Kumacheva · Nature Synthesis · 2023 · 506 citations · Full text

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Machine learning meets continuous flow chemistry: Automated optimization towards the Pareto front of multiple objectives

Artur M. Schweidtmann, Adam D. Clayton, Nicholas Holmes et al. · Chemical Engineering Journal · 2018 · 358 citations · Full text

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“Batch” Kinetics in Flow: Online IR Analysis and Continuous Control

Jason S. Moore, Klavs F. Jensen · Angewandte Chemie International Edition · 2013 · 166 citations · Full text

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Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow**

Peter Sagmeister, René Lebl, Ismaël Castillo et al. · Angewandte Chemie International Edition · 2021 · 158 citations · Full text

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