Nicholas Holmes

Machine learning meets continuous flow chemistry: Automated optimization towards the Pareto front of multiple objectives

Artur M. Schweidtmann, Adam D. Clayton, Nicholas Holmes et al. · Chemical Engineering Journal · 2018 · 345 citations · Full text

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Nicholas Holmes, Geoffrey R. Akien, Robert J. D. Savage et al. · Reaction Chemistry & Engineering · 2015 · 131 citations · Full text

Engineering, Industrial Engineering, Organic Chemistry +23

Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

Nicholas Holmes, Geoffrey R. Akien, A. John Blacker et al. · Reaction Chemistry & Engineering · 2016 · 118 citations · Full text

Engineering, Evolutionary Algorithms, Biochemical Engineering +20

Rapid multistep kinetic model generation from transient flow data

Christopher A. Hone, Nicholas Holmes, Geoffrey R. Akien et al. · Reaction Chemistry & Engineering · 2016 · 101 citations · Full text

Enhanced process development using automated continuous reactors by self-optimisation algorithms and statistical empirical modelling

Mohammed I. Jeraal, Nicholas Holmes, Geoffrey R. Akien et al. · Tetrahedron · 2018 · 49 citations

Process Integration, Process Design, Enhanced Process Development +10