Concepedia

T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation

Abraham Bayer, Sasha Smolgovsky, Njabulo Ngwenyama, Ana Hernández Martínez, Kuljeet Kaur, Katherine B. Sulka, Junedh Amrute, Mark Aronovitz, Kory J. Lavine, Shruti Sharma,

Circulation Research · 2023 · 26 citations · 35 references

DOIFull text

Open access

Abstract

Our results outline a novel intrinsic role for MyD88 in limiting T-cell activation that is central to tune down cardiac inflammation during cardiac adaptation to stress.

References

35

Integrated analysis of multimodal single-cell data

Yuhan Hao, Stephanie Hao, Erica Andersen‐Nissen et al. · Cell · 2021 · 14.9K citations · Full text

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Paul M. Ridker, Tom Thurén, Jean MacFadyen et al. · New England Journal of Medicine · 2017 · 8.7K citations · Full text

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Osamu Adachi, Taro Kawai, Kiyoshi Takeda et al. · Immunity · 1998 · 2K citations · Full text

, , +11

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

Eugene S. Chung, Milton Packer, Kim Hung Lo et al. · Circulation · 2003 · 1.6K citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

Peggy P. Lee, David Fitzpatrick, Caroline Beard et al. · Immunity · 2001 · 1.3K citations · Full text

, , +14