<i>Roseburia intestinalis</i> generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 ⁺ T cells

Abstract

<i>R. intestinalis</i> protects against colorectal tumourigenesis by producing butyrate, which could also improve anti-PD-1 efficacy by inducing functional CD8⁺ T cells. <i>R. intestinalis</i> is a potential adjuvant to augment anti-PD-1 efficacy against CRC.