Robustness of tissue oxygenation estimates by continuous wave space-resolved near infrared spectroscopy

Abstract

Significance: ] and the modeling of tissue as homogeneous. Aim: was varied from expected values, and when layered tissue was considered. Approach: ) and their relative error. Results: when the superficial thickness exceeds 5 mm. Conclusions: These results highlight the need for more sophisticated strategies (e.g., the use of multiple short and long distances) to reduce the influence of superficial tissues in retrieving hemodynamic parameters and warn the SRS users to be aware of the intrinsic limitation of this approach, particularly when exploited in the clinical environment.