Concepedia

Publication | Open Access

Oxidised IL-33 drives COPD epithelial pathogenesis<i>via</i>ST2-independent RAGE/EGFR signalling complex

DOIFull Paper Access

71

Citations

32

References

2023

Year

Sam Strickson, Kirsty F. Houslay, Victor Augusti Negri, Yoichiro Ohne, Tomas Ottosson, Roger B. Dodd, Catherine Huntington, Tina Baker, Jingjing Li, Katherine Stephenson,
European Respiratory Journal

Abstract

Our study reveals for the first time that IL-33, RAGE and EGFR act together in an ST2-independent pathway in the airway epithelium and govern abnormal epithelial remodelling and muco-obstructive features in COPD.

References

YearCitations

Page 1