IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations <i>In Vivo</i>

Abstract

IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo. Virus-induced IL-33 and IL-33-responsive T cells and ILC2s are key mechanistic links between viral infection and exacerbation of asthma. IL-33 inhibition is a novel therapeutic approach for asthma exacerbations.