Concepedia

Separation of bispecific antibody related impurities with mixed-mode chromatography

Mingkai Song, Hui Yang, Wanting Cao, Qingqing Liu

Process Biochemistry · 2023 · 18 citations · 20 references

DOI

Concepts

References

20

‘Knobs-into-holes’ engineering of antibody C<sub>H</sub>3 domains for heavy chain heterodimerization

John Brady Ridgway, Leonard G. Presta, Paul Carter · Protein Engineering Design and Selection · 1996 · 802 citations

, , +15

Planar Stacking Interactions of Arginine and Aromatic Side-Chains in Proteins

Maria M. Flocco, Sherry L. Mowbray · Journal of Molecular Biology · 1994 · 292 citations

, , +13

Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity

Andrew D. Tustian, Christine E. Endicott, Benjamin Adams et al. · mAbs · 2016 · 123 citations · Full text

, , +17

The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography

Tsutomu Arakawa, Kouhei Tsumoto, Kazuo Nagase et al. · Protein Expression and Purification · 2007 · 111 citations

, , +15

The Mighty Arginine, the Stable Quaternary Amines, the Powerful Aromatics, and the Aggressive Phosphate:  Their Role in the Noncovalent Minuet

Amina S. Woods · Journal of Proteome Research · 2004 · 103 citations

, , +17