A randomised, double‐blind, placebo‐controlled study of the <scp>LAG</scp>‐3‐depleting monoclonal antibody <scp>GSK2831781</scp> in patients with active ulcerative colitis

Abstract

Despite evidence of target cell depletion in blood, GSK2831781 failed to reduce inflammation in the colonic mucosa suggesting no pharmacological effect. The study was terminated early (NCT03893565).