Polygonatum kingianum saponins delay cellular senescence through SASP down-regulation and prolong the healthy lifespan of Caenorhabditis elegans by activating sir-2.1/autophagy

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4.1K citations · Full text

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

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Life Sciences, Biochemistry, Molecular Biology +15

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text

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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17