Concepedia

Vitamin D supplementation alleviates insulin resistance in prediabetic rats by modifying IRS-1 and PPARγ/NF-κB expressions

Desak Gede Budi Krisnamurti, Melva Louisa, Erni Hernawati Poerwaningsih, Tri Juli Edi Tarigan, Vivian Soetikno, Heri Wibowo, Christian Marco Hadi Nugroho

Frontiers in Endocrinology · 2023 · 37 citations · 26 references

DOIFull text

Open access

Abstract

Vitamin D supplementation reduces insulin resistance in prediabetic rats. The reduction might be due to the effects of vitamin D on IRS, PPARγ, and NF-κB expression.

References

26

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Vincent Aguirre, Eric D. Werner, Jodel Giraud et al. · Journal of Biological Chemistry · 2002 · 980 citations · Full text

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

Zhigang Liu, Ishan Patil, Tianyi Jiang et al. · PLoS ONE · 2015 · 226 citations · Full text

, , +18

Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy

Vivian Soetikno, Flori R. Sari, Punniyakoti T. Veeraveedu et al. · Nutrition & Metabolism · 2011 · 216 citations · Full text

, , +24

1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion.

Soo Jin Lee, Sam Clark, Rupinder Kaur Gill et al. · Endocrinology · 1994 · 192 citations

, , +13

PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle

A.H.V. Remels, Ramon Langen, Harry R. Gosker et al. · American Journal of Physiology-Endocrinology and Metabolism · 2009 · 181 citations · Full text

, , +19