Concepedia

Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial

Bruno François, Simon Lambden, Tom Fivez, Sébastien Gibot, Marc Derive, Jean‐Marie Grouin, Margarita Salcedo‐Magguilli, Jérémie Lemarie, Nicolas De Schryver, Ville Jalkanen,

The Lancet Respiratory Medicine · 2023 · 74 citations · 17 references

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References

17

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer, Clifford S. Deutschman, Christopher W. Seymour et al. · JAMA · 2016 · 28K citations · Full text

, , +17

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Laura Evans, Andrew Rhodes, Waleed Alhazzani et al. · Intensive Care Medicine · 2021 · 5K citations · Full text

, , +16

Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

Axel Bouchon, Jes Dietrich, Marco Colonna · The Journal of Immunology · 2000 · 1.3K citations

, , +17

A genomic storm in critically injured humans

Wenzhong Xiao, Michael Mindrinos, Junhee Seok et al. · The Journal of Experimental Medicine · 2011 · 1.2K citations · Full text

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

Axel Bouchon, Fabio Facchetti, Markus A. Weigand et al. · Nature · 2001 · 1.1K citations

, , +16