HRG inhibits liver cancer lung metastasis by suppressing neutrophil extracellular trap formation

Yanze Yin, Huijuan Dai, Xicheng Sun, Zhifeng Xi, Jiang Zhang, Yixiao Pan, Yongxin Huang, Xueyun Ma, Qiang Xia, Kang He

Clinical and Translational Medicine · 2023 · 43 citations · 22 references

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Abstract

Our study reveals that liver cancer regulates neutrophil recruitment and NETs formation in the metastatic microenvironment by reducing HRG secretion, thereby promoting tumour lung metastasis. The results of this study will contribute to the development of possible strategies for treating metastases.

References

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