RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8+ T cell infiltration in colorectal cancer

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Surgical Oncology, Epidemiology Of Cancer, Gastroenterology +21

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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Rna Metabolism, Developmental Biology, Genetics +9

Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

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m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

Sicong Zhang, Boxuan Zhao, Aidong Zhou et al. · Cancer Cell · 2017 · 1.5K citations · Full text

Tumor Biology, Glioma, Medicine +12

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m ⁶ A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu et al. · Proceedings of the National Academy of Sciences · 2016 · 1K citations · Full text