Food & Function · 2023 · 32 citations · 33 references
MedicineMedicinal ChemistryPharmacologyApoptosisInflammationMolecular PharmacologyAnti-inflammatory PharmacologyGastrointestinal InflammationGastrointestinal PharmacologyInflammation PharmacologyInflammatory SignalingOxidative Stress In InflammationDrug-induced Mucosal InjuryGastric Ulcer PreventionGastrointestinal Inflammatory InjuryGastroprotective AgentsGastroprotective TherapyMucosal ProtectionOxidative Stress InflammationOxidative Stress Injury
blockade of proinflammatory mitogen-activated protein kinase-nuclear factor κB (MAPK/NF-κB) signaling pathways. Furthermore, ginsenoside Rh4 significantly enhanced the protein expression of B-cell lymphoma gene 2 (Bcl-2), decreased the protein expression of Bcl-2-associated X protein (Bax) and tumor necrosis factor receptor superfamily member 6 (Fas), and inhibited the number of apoptotic cells in gastric tissues. The present work demonstrated that ginsenoside Rh4 exerted a considerable gastroprotective effect against ethanol-induced gastric ulcers in rats.
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