Uncoupling CD4+ TIL-Mediated Tumor Killing from JAK-Signaling in Melanoma

Abstract

In conclusion, our data indicate that exploiting tumor-specific cytotoxic CD4+ TILs could help overcome resistance to ICB mediated by IFNγ-signaling loss in MHCIIconst+ melanomas. See related commentary by Betof Warner and Luke, p. 3829.