Palmitic Acid–Induced Long Noncoding RNA <i>PARAIL</i> Regulates Inflammation via Interaction With RNA-Binding Protein ELAVL1 in Monocytes and Macrophages

Abstract

Upregulation of <i>PARAIL</i> under acute inflammatory conditions contributes to proresolution mechanisms via <i>PARAIL</i>-ELAVL1 interactions. Conversely, <i>PARAIL</i> downregulation in cardiometabolic diseases enhances ELAVL1 function and impairs inflammation resolution to further augment inflammation. Thus, inflammation-resolving lncRNAs like <i>PARAIL</i> represent novel targets to combat inflammatory cardiometabolic diseases.