Iron overload induces islet β cell ferroptosis by activating ASK1/P-P38/CHOP signaling pathway

Abstract

Iron overload induces MIN6 cell dysfunction, leading to increased fasting blood glucose, impaired glucose tolerance, and significantly decreased insulin sensitivity in mice. This process may be related to the ferroptosis of islet β cells and the activation of ASK1/P-P38/CHOP signaling pathway.