Rational Design of <i>Meso</i> -Diaminopimelate Dehydrogenase with Enhanced Reductive Amination Activity for Efficient Production of <scp>d</scp> - <i>p</i> -Hydroxyphenylglycine

Abstract

d - p -hydroxyphenylglycine ( d -HPG) is an important intermediate in the synthesis of antimicrobial compounds. d -HPG is mainly produced via chemical and enzymatic approaches, and enzymatic asymmetric amination employing diaminopimelate dehydrogenase (DAPDH) is considered an attractive method.