Expressing IL-15/IL-18 and CXCR2 improve infiltration and survival of EGFRvIII-targeting CAR-T cells in breast cancer

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Dori A. Thomas, Joan Massagué · Cancer Cell · 2005 · 1.3K citations · Full text

Life Sciences, Immunology, Oncology +16

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Emmanuelle Charafe‐Jauffret, Christophe Ginestier, Flora Iovino et al. · Cancer Research · 2009 · 1.2K citations · Full text

Medicine, Cell Biology, Oncology +17

The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

Audrey Kinter, Emily Godbout, Jonathan P. McNally et al. · The Journal of Immunology · 2008 · 509 citations · Full text

Life Sciences, Immunology, Adaptive Immunity +12

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

Biliang Hu, Jiangtao Ren, Yanping Luo et al. · Cell Reports · 2017 · 494 citations · Full text

Life Sciences, Immunology, Oncology +17

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

Markus Chmielewski, Hinrich Abken · Cell Reports · 2017 · 416 citations · Full text

Life Sciences, Immunology, Oncology +17