Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low

Abstract

This study suggests that HER2_low TNBC patients harbor more malignant clinical behavior and aggressive tumor biological properties than the HER2_neg phenotype. The heterogeneity of HER2 may be a non-negligible factor in the clinical management of TNBC patients. Our data provide new insights into the development of a more refined classification and tailored therapeutic strategies for TNBC patients.