International Journal of Nanomedicine · 2023 · 13 citations · 26 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryVirologyAntiviral AgentsAntiviral TherapyLipid-based NanoparticlesNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignAntiviral TherapeuticsAntiviral TreatmentLipid NanomaterialsLipid Nanoparticle Delivery SystemsLipid NanoparticlesLipid-based Nanoparticle FormulationNanoparticle Cellular UptakeSars-cov-2 Antiviral Therapy
Introduction: The ongoing SARS-CoV-2 pandemic has affected public health, the economy, and society. This study reported a nanotechnology-based strategy to enhance the antiviral efficacy of the antiviral agent remdesivir (RDS). Results: We developed a nanosized spherical RDS-NLC in which the RDS was encapsulated in an amorphous form. The RDS-NLC significantly potentiated the antiviral efficacy of RDS against SARS-CoV-2 and its variants (alpha, beta, and delta). Our study revealed that NLC technology improved the antiviral effect of RDS against SARS-CoV-2 by enhancing the cellular uptake of RDS and reducing SARS-CoV-2 entry in cells. These improvements resulted in a 211% increase in the bioavailability of RDS. Conclusion: Thus, the application of NLC against SARS-CoV-2 may be a beneficial strategy to improve the antiviral effects of antiviral agents.
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Cytokine release syndrome in severe COVID-19
John B. Moore, Carl H. June · Science · 2020 · 2K citations