Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation

Rafaela dos Santos, Flávio P. Veras, Gonçalves Netto, Lívia Elisei, Carlos A. Sorgi, Lúcia Helena Faccioli, Giovane Galdino

Journal of Pharmacy and Pharmacology · 2023 · 15 citations · 29 references

Abstract

CBD was efficient in preventing PTX-induced neuropathic pain, and this effect may involve inhibition of the TLR4 on microglia spinal with activation of the endocannabinoid system.

References

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