Concepedia

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning <i>via</i> Activating the AC3/PKA/HSL Pathway

Xifen Zheng, Wenting Huang, Qianbei Li, Yun Chen, Linyan Wu, Yifan Dong, Xinyue Huang, Xiaojing He, Zihao Ou, Yongzheng Peng

Microbiology Spectrum · 2023 · 52 citations · 23 references

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Concepts

Abstract

the AC3/PKA/HSL pathway, phosphorylating HSL at Ser 660. The experiments illustrated here identify the specific molecules and functional mechanisms of Akk. Therapeutic approaches with Amuc_1100 derived from Akk may help alleviate obesity and metabolic disorders.

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