Publication | Closed Access
The Inhibitory Quotient
94
Citations
0
References
1981
Year
Aldo-keto ReductaseQuantitative PharmacologyPharmacotherapyDrug ResistanceMinimum Inhibitory ConcentrationAntimicrobial StewardshipInhibitory QuotientClinical EpidemiologyDrug MonitoringClinical ChemistryAntimicrobial ResistanceInhibitory ActivityDrug InteractionsTherapeutic Drug MonitoringBiochemistryMechanism Of ActionAntimicrobial PharmacokineticsPharmacologyAntimicrobial SusceptibilityInhibitory QuotientsAntibioticsAntimicrobial PharmacodynamicsMedicinePharmacokineticsDrug DiscoveryDrug Analysis
A method for reporting minimum inhibitory concentration (MIC) data that facilitates interpretation by the clinician unfamiliar with clinically achievable drug levels is described. This system uses the inhibitory quotient, which is a number reflecting the multiple of the MIC that would be achieved. Inhibitory quotients are determined for blood, urine, bile, and CSF and reflect achievable drug levels in those body fluids. The use of inhibitory quotients can be extremely helpful to the physician in the rational selection of an appropriate antimicrobial agent. (<i>JAMA</i>1981;246:1575-1578)