Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

Arturo Roca-Rivada, Cecilia Castelao, Lucía L. Senín et al. · PLoS ONE · 2013 · 601 citations · Full text

Muscle Tissue, Adipokines, Metabolic Syndrome +17

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark P. Jedrychowski et al. · Cell · 2018 · 590 citations · Full text

αV Integrin Receptors, Molecular Physiology, Signal Transduction +10

Patterns of Brain Injury in Neonates Exposed to Perinatal Sentinel Events

Akudo Okereafor, Joanna Allsop, Serena J. Counsell et al. · PEDIATRICS · 2008 · 310 citations

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Jianbin Bi, Jia Zhang, Yifan Ren et al. · Redox Biology · 2018 · 291 citations · Full text