Concepedia

The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria

Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C. Yap, Christine S. Gibhardt, Giang N. T. Le, Saaya Hario, Yusuke Nasu, Jack Moore, Tomás Gutiérrez,

Cell Reports · 2022 · 107 citations · 66 references

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Concepts

Abstract

flux to maintain bioenergetics in both organelles, while limiting oxidative stress. Therefore, the PERK-ERO1⍺ complex is a key molecular machinery that allows quick metabolic adaptation to ER stress.

References

66

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

Jordi Folch, Marjorie B. Lees, G H S Stanley · Journal of Biological Chemistry · 1957 · 64.9K citations · Full text

, , +11

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Olga Martins de Brito, Luca Scorrano · Nature · 2008 · 2.4K citations

, , +14

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca <sup>2+</sup> Responses

Rosario Rizzuto, Paolo Pinton, Walter Carrington et al. · Science · 1998 · 2.2K citations

, , +17

Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

Teruo Hayashi, Tsung‐Ping Su · Cell · 2007 · 1.8K citations · Full text

, , +14

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Lígia C. Gomes, Giulietta Di Benedetto, Luca Scorrano · Nature Cell Biology · 2011 · 1.7K citations · Full text

, , +12