The Journal of Immunology · 1971 · 31 citations · 0 references
Life SciencesImmunologyMicrobiologyImmunology Of Infectious DiseasesInnate ImmunityVirologyHumoral ImmunityPolysaccharide PropertiesPolysaccharide StructureBacterial PolysaccharidesCapsular Polysaccharide ImmunologyCapsular PolysaccharidesMolecular Weight DeterminationPolysaccharide CharacterizationPolysaccharide PurificationUltracentrifugation
Abstract The capsular substance of H. influenzae type b was isolated in a highly purified form. Serologic identity was demonstrated among the polysaccharides of seven different strains of H. influenzae type b. The polysaccharide had a molecular weight greater than 200,000 estimated by gel filtration and 152,000 by analytic ultracentrifugation and was shown to be relatively non-toxic and non-pyrogenic for laboratory animals.