Concepedia

cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

Sarinya Kumpunya, Arthid Thim-uam, Chisanu Thumarat, Asada Leelahavanichkul, Nuttiya Kalpongnukul, Naphat Chantaravisoot, Trairak Pisitkun, Prapaporn Pisitkun

Frontiers in Immunology · 2022 · 22 citations · 46 references

DOIFull text

Open access

Abstract

These findings suggested that cGAS hampers the unusual noncanonical inflammasome activation through other DNA sensors.

References

46

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.6K citations · Full text

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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STING is a direct innate immune sensor of cyclic di-GMP

Dara Burdette, Kathryn M. Monroe, Katia Troha et al. · Nature · 2011 · 1.5K citations

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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Xiang Gui, Hui Yang, Tuo Li et al. · Nature · 2019 · 1.2K citations · Full text

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DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Mingjian Du, Zhijian J. Chen · Science · 2018 · 975 citations · Full text

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