Concepedia

Mesencephalic astrocyte-derived neurotrophic factor (MANF) prevents the neuroinflammation induced dopaminergic neurodegeneration

Jingxing Zhang, Kai-Ge Zhou, Yanxin Yin, Lingjing Jin, Weifang Tong, Jia Guo, Lihua Yu, Xian-Cheng Ye, Ming Jiang

Experimental Gerontology · 2022 · 20 citations · 26 references

DOIFull text

Open access

Abstract

These results suggested that the MANF prevented the dopaminergic neurodegeneration caused by the microglia activation in PD via activation of the AKT/GSK3β-Nrf-2 signaling axis.

References

26

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

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Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

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Immune modulation by MANF promotes tissue repair and regenerative success in the retina

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Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles

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MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

Maria Lindahl, Tatiana Danilova, Erik Palm et al. · Cell Reports · 2014 · 196 citations · Full text