Tumor immune microenvironment in endometrial cancer of different molecular subtypes: evidence from a retrospective observational study

Abstract

Endometrial cancer of TMB-H, NSMP and <i>TP53</i> mutant subtypes displayed phenotypes of normal immune response, absence of immune infiltration, and suppressed immune response, respectively. These features may provide mechanistic explanations for the differences in patients' prognosis and efficacy of immune checkpoint blockade therapies among different endometrial cancer subtypes.