Concepedia

Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors

Adrian Krzyzanowski, Lea Marie Esser, Anthony Willaume, Renaud Prudent, Christoph Peter, Peter ‘t Hart, Herbert Waldmann

Journal of Medicinal Chemistry · 2022 · 29 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

= 654 nM) but not with the alternative adaptor protein MEP50. The inhibitor is a promising tool for further biological investigation of this intriguing protein interface.

References

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