Concepedia

Macrocyclic Peptide Libraries

Macrocyclic Peptide Libraries is a combinatorial library comprising structurally diverse peptides constrained by covalent cyclic architectures that enhance conformational stability and bioactivity, distinguished by their closed-loop topology that enables selective target binding and improved pharmacokinetic properties relative to linear peptides.

193

Publications

9.3K

Citations

1.1K

Authors

280

Institutions

Publications per year

2017–2026

97

Variants

Macrocyclic Peptide Library

Parents

Publications

193

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

Y. Yamagishi, Ikuo Shoji, Shoji Miyagawa et al. · Chemistry & Biology · 2011 · 356 citations

, , +14

The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides

Yuki Goto, Hiroaki Suga · Accounts of Chemical Research · 2021 · 248 citations · Full text

, , +17

A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation

Xuekai Zhang, Gang Lü, Meng Sun et al. · Nature Chemistry · 2018 · 244 citations

, , +12

<i>In Vitro</i> Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

Yollete V. Guillén Schlippe, Matthew C. T. Hartman, Kristopher Josephson et al. · Journal of the American Chemical Society · 2012 · 241 citations · Full text

, , +14

Designing macrocyclic disulfide-rich peptides for biotechnological applications

Conan K. Wang, David J. Craik · Nature Chemical Biology · 2018 · 229 citations

, , +14

1–5 of 193

Authors

1.1K

  1. HS
    Hiroaki Suga

    The University of Tokyo, Japan

    34 publications · 2.2K citations

    25

    h-index

  2. TK
    Takayuki Katoh

    The University of Tokyo, Japan

    10 publications · 678 citations

    10

    h-index

  3. RF
    Rudi Fasan

    University of Rochester, United States

    6 publications · 332 citations

    6

    h-index

  4. PR
    Patrick Reid

    Peptidream (Japan), Japan

    5 publications · 256 citations

    5

    h-index

  5. RD
    Ratmir Derda

    University of Alberta, Canada

    5 publications · 271 citations

    5

    h-index

1–5 of 1.1K

Institutions

280

  1. The University of Tokyo

    Tokyo, Japan

    26 h-index

    116 publications

    7.7K citations

  2. University of Rochester

    Rochester, United States

    6 h-index

    24 publications

    1.3K citations

  3. Peptidream (Japan)

    Tokyo, Japan

    6 h-index

    7 publications

    314 citations

  4. University of Alberta

    Edmonton, Canada

    5 h-index

    29 publications

    1.8K citations

  5. University of California, Santa Cruz

    Santa Cruz, United States

    5 h-index

    18 publications

    752 citations

  6. National Institutes of Health

    Bethesda, United States

    5 h-index

    17 publications

    453 citations

  7. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    5 h-index

    22 publications

    903 citations

  8. The University of Osaka

    Osaka, Japan

    4 h-index

    13 publications

    545 citations

1–8 of 280

Venues

  1. Journal of the American Chemical Society

    JACS · 21 publications · 1.2K citations

    20

    h-index

  2. Angewandte Chemie International Edition

    13 publications · 881 citations

    13

    h-index

  3. Journal of Medicinal Chemistry

    13 publications · 506 citations

    12

    h-index

  4. Organic Letters

    OL · 11 publications · 376 citations

    11

    h-index

  5. ACS Chemical Biology

    10 publications · 658 citations

    10

    h-index

1–5