Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway

CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

Kenneth E. Lipson, Carol Wong, Yuchin Teng et al. · Fibrogenesis & Tissue Repair · 2012 · 578 citations · Full text

Veterinary Medicine, Pathobiology, Pathology +17

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

Yingying Wang, Hong Jiang, Jun Pan et al. · Journal of the American Society of Nephrology · 2017 · 429 citations · Full text

Medicine, Pathobiology, Pathology +16

Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET)

Fang Wang, Chao Yang, Jianyan Long et al. · Kidney International · 2019 · 160 citations · Full text

Medicine, Internal Medicine, Nephrology +15

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF-κB

Elsa Sánchez‐López, Sandra Rayego‐Mateos, Raquel Rodrigues‐Díez et al. · Journal of the American Society of Nephrology · 2009 · 138 citations · Full text

Medicine, Nephrology, Pathology +17

CTGF/CCN2 is an autocrine regulator of cardiac fibrosis

Lisa E. Dorn, Jennifer M. Petrosino, Patrick Wright et al. · Journal of Molecular and Cellular Cardiology · 2018 · 132 citations

Life Sciences, Cardiology, Physiology +14