Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

Inflammation, Signal Transduction, Signaling Pathway +12

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.3K citations

Inflammation, Mitochondrial Function, Cell Death +7

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.1K citations · Full text

Inflammation, Apoptosis, Cell Death +7

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3K citations

Medicine, Apoptosis, Pyroptosis +9

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding, Kun Wang, Wang Liu et al. · Nature · 2016 · 2.6K citations

Gasdermin Family, Protein Secretion, Biochemistry +2