2’-Fucosyllactose inhibits proliferation of Clostridioides difficile ATCC 43599 in the CDi-screen, an in vitro model simulating Clostridioides difficile infection

Abstract

The CDi-screen is suitable for studying <i>C. difficile</i> proliferation in a complex gut ecosystem and for screening for anti-pathogenic interventions that target <i>C. difficile</i> directly and/or indirectly through interactions with the gut microbiota. Different doses of compounds such as in this study the dose of the human milk oligosaccharide 2'-FL can be screened for efficacy in the inhibition of <i>C. difficile</i> proliferation.