Concepedia

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

Ross J. Collins, Hyun-Ah Lee, D. Heulyn Jones, Jonathan M. Elkins, Jason A. Gillespie, Carys Thomas, Alex G. Baldwin, Kimberley Jones, Loren Waters, Marie Paine,

Journal of Medicinal Chemistry · 2022 · 23 citations · 29 references

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Abstract

pharmacological tools for the study of LIMK function in cell biology.

References

29

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

Neng Yang, Osamu Higuchi, Kazumasa Ohashi et al. · Nature · 1998 · 1.3K citations

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The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 850 citations · Full text

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Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin

Ryusuke Niwa, Kyoko Nagata-Ohashi, Masatoshi Takeichi et al. · Cell · 2002 · 690 citations · Full text

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Rescue of fragile X syndrome phenotypes in <i>Fmr1</i> KO mice by the small-molecule PAK inhibitor FRAX486

Bridget Dolan, Sergio G. Durón, David A. Campbell et al. · Proceedings of the National Academy of Sciences · 2013 · 277 citations · Full text

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Phosphorylation of Actin-Depolymerizing Factor/Cofilin by LIM-Kinase Mediates Amyloid  -Induced Degeneration: A Potential Mechanism of Neuronal Dystrophy in Alzheimer's Disease

Luís Heredia, Pablo Helguera, Soledad de Olmos et al. · Journal of Neuroscience · 2006 · 181 citations · Full text

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