Elevated Levels of Basic Fibroblast Growth Factor in the Urine of Clam Enterocystoplasty Patients

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Feb 1996Elevated Levels of Basic Fibroblast Growth Factor in the Urine of Clam Enterocystoplasty Patients J.W. Barrington, L. Fraylin, R. Fish, M. Shelley, and T.P. Stephenson J.W. BarringtonJ.W. Barrington More articles by this author , L. FraylinL. Fraylin More articles by this author , R. FishR. Fish More articles by this author , M. ShelleyM. Shelley More articles by this author , and T.P. StephensonT.P. Stephenson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66420-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether basic fibroblast growth factor is elevated in the urine of patients who have undergone clam ileocystoplasty. Materials and Methods: An immunoassay technique was used to measure urinary basic fibroblast growth factor in 50 patients equally divided between those with and without neuropathy who had undergone clam enterocystoplasty. The results were compared with urinary basic fibroblast growth factor concentrations from 25 healthy age and sex matched volunteers. Results: There is a highly significant elevation of urinary basic fibroblast growth factor in clam enterocystoplasty patients compared to controls, which is not related to the presence or absence of infection. There is no difference between those with and without neuropathy. Conclusions: Elevated levels of basic fibroblast growth factor are an important consideration in the malignant potential of the clam procedure. References 1 : Treatment of the neuropathic bladder by enterocystoplasty and selective sphincterotomy or sphincter ablation and replacement. Brit. J. Urol.1985; 57: 27. Google Scholar 2 : ‘Clam’ ileocystoplasty for the treatment of refractory urge incontinence. Brit. J. Urol.1985; 57: 641. Google Scholar 3 : The treatment of adult enuresis and urge incontinence by enterocystoplasty. Brit. J. Urol.1982; 54: 693. Google Scholar 4 : Malignancies in bladder augmentations and intestinal conduits. J. Urol.1990; 143: 671. Link, Google Scholar 5 : Assessment of the malignant potential of cystoplasty. Brit. J. Urol.1989; 64: 489. Google Scholar 6 : Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients. J. Nat. Cancer Ints.1993; 85: 241. Google Scholar 7 : Identification of basic fibroblast growth factor sensitivity and receptor and ligand expression in human colon tumor cell lines. J. Cell. Physiol.1992; 150: 320. Google Scholar 8 : Extracellular matrix-resident basic fibroblast growth factor: implication for the control of angiogenesis. J. Cell. Biochem.1991; 45: 167. Google Scholar 9 : Endothelial-cell proliferation in experimental tumours. Brit. J. Cancer1982; 46: 711. Google Scholar 10 : Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action. Cancer Res.1994; 54: 2347. Google Scholar 11 : Growth factors in development, transformation, and tumorigenesis. Cell1991; 64: 271. Google Scholar 12 : Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J. Nat. Cancer Inst.1994; 86: 356. Google Scholar 13 : Angiogenic factors. Science1987; 235: 442. Google Scholar 14 : Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature1989; 339: 58. Google Scholar Department of Urology, Cardiff Royal Infirmary and Research Laboratories, Velindre NHS Trust Hospital, Cardiff, South Glamorgan, United Kingdom.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMUNRO N and KNOWLES M (2018) Fibroblast Growth Factors and Their Receptors in Transitional Cell CarcinomaJournal of Urology, VOL. 169, NO. 2, (675-682), Online publication date: 1-Feb-2003.Bagli D, Van Savage J, Khoury A, Carr M and McLorie G (2018) Basic Fibroblast Growth Factor in the Urine of Children with Voiding PathologyJournal of Urology, VOL. 158, NO. 3, (1123-1127), Online publication date: 1-Sep-1997.Barrington J, Fulford S, Griffiths D and Stephenson T (2018) Tumors in Bladder Remnant After Augmentation EnterocystoplastyJournal of Urology, VOL. 157, NO. 2, (482-486), Online publication date: 1-Feb-1997. Volume 155Issue 2February 1996Page: 468-470 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information J.W. Barrington More articles by this author L. Fraylin More articles by this author R. Fish More articles by this author M. Shelley More articles by this author T.P. Stephenson More articles by this author Expand All Advertisement PDF downloadLoading ...