Concepedia

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics

Karthik A. Jagadeesh, Kushal K. Dey, Daniel T. Montoro, Rahul Mohan, Steven Gazal, J Engreitz, Ramnik J. Xavier, Alkes L. Price, Aviv Regev

Nature Genetics · 2022 · 247 citations · 79 references

Open access

Concepts

Life SciencesCell BiologyMolecular BiologyGene ExpressionGenomicsTranscriptomicsCell-type-specific TranscriptomicsSingle-cell AnalysisSingle-cell GenomicsSingle-cell IntegrationSingle-cell Rna Sequencing AnalysisSingle-cell TranscriptomicsCell Type ResolutionRare Cell Type DiscoverySingle-cell Rna SequencingSingle-cell Rna Sequencing Cell Type AnnotationSingle-cell Rna Sequencing IntegrationSingle-cell Single-nucleotide Variant CallingSingle-cell Transcriptome Integration

References

79

A global reference for human genetic variation

Richard Durbin, Peter Donnelly, Paul Flicek et al. · Nature · 2015 · 20K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Learning the parts of objects by non-negative matrix factorization

Daniel D. Lee, H. Sebastian Seung · Nature · 1999 · 14.1K citations

Computing, Computer Science, Computer Vision +11

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov, Matthew R. Jones, Andrew D. Rouillard et al. · Nucleic Acids Research · 2016 · 11.7K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +10

Fast, sensitive and accurate integration of single-cell data with Harmony

Ilya Korsunsky, Nghia Millard, Jean Fan et al. · Nature Methods · 2019 · 10.5K citations · Full text

Life Sciences, Bioinformatics, Cell Biology +14

SCANPY: large-scale single-cell gene expression data analysis

F. Alexander Wolf, Philipp Angerer, Fabian J. Theis · Genome biology · 2018 · 9.3K citations · Full text

Life Sciences, Bioinformatics, Cell Biology +15