Concepedia

S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy

Zhiqiang Xie, Liqing Lu, Zhenghua Wang, Qinhong Luo, Yuchen Yang, Tian Fang, Ziyi Chen, Dejun Ma, Junmin Quan, Zhen Xi

European Journal of Medicinal Chemistry · 2022 · 25 citations · 36 references

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References

36

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

, , +16

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Jiaxi Wu, Lijun Sun, Xiang Chen et al. · Science · 2012 · 2.5K citations

, , +17

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

, , +12

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter et al. · Cell Reports · 2015 · 1.5K citations · Full text

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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Xiao-Dong Li, Jiaxi Wu, Daxing Gao et al. · Science · 2013 · 1.1K citations · Full text

, , +17