Cell Reports · 2022 · 40 citations · 65 references
Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyImmune Checkpoint InhibitorsImmune Checkpoint RegulationImmune CheckpointsCd4 Positive T CellsCell-mediated ImmunosuppressionChemotactic MediatorsImmune Checkpoint ResistanceImmunosuppressive MicroenvironmentProgrammed Cell Death Protein 1 (Pd-1) PathwayProgrammed Death-ligand 1 InhibitorsResistance To Immune Checkpoint Inhibition
gene signature associates with worse survival in patients with BTC as well as in other anti-PD-1 refractory cancers. These results demonstrate that monocytes arising after anti-PD-1 treatment can induce T cell paralysis as a distinct mode of tumor-mediated immunosuppression leading to CPI resistance.
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STAR: ultrafast universal RNA-seq aligner
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Gene Ontology: tool for the unification of biology
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Medicine, Bioinformatics, Oncology +15