Development of Cu(<scp>ii</scp>)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

Abstract

The synthetic peptide AKH-αR5W4 NBD was designed as a shuttle to counteract copper imbalance in Alzheimer’s disease. In vitro , this shuttle is able to abstract Cu( ii ) selectively from amyloid-β and transport it into cells in a bioavailable form.