Concepedia

Publication | Open Access

The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth <i>In Vivo</i> and Potentiates Radiotherapy

DOIFull Paper Access

13

Citations

36

References

2022

Year

Katrine Ingelshed, Diana Spiegelberg, Pavitra Kannan, Linnéa Påvénius, Jessica Hacheney, Long Jiang, Silke Eisinger, Danai Lianoudaki, Dilraj Lama, Francisca Castillo,
Cancer Research Communications

Abstract

The MDM2 inhibitor Navtemadlin arrests mouse tumor growth and potentiates radiotherapy. Our results support a threshold model for apoptosis induction that requires a high, prolonged p53 signaling for cancer cells to become apoptotic.

References

YearCitations

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