ACS Chemical Biology · 2022 · 19 citations · 50 references
Life SciencesImmunologyInfectious DiseasesImmunizationVaccine ImmunologyVaccinologyDendritic Cell BiologyImmune Response To VaccinationNeonatal ImmunityVaccinationVaccine DeliveryVaccine PlatformsAdjuvant DeliveryCd4 T Cell ActivationImmune Responses To Early-life VaccinationNeonatal Dendritic CellsNeonatal ImmunizationT Cell ExpansionT Follicular Helper Cell ActivationT Follicular Helper Cells
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation system via age-selected small-molecule synergy and a multicomponent nanocarrier formulation as an effective approach to induce type 1 immune responses in early life.
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