Concepedia

A base-catalyzed approach for the anti-Markovnikov hydration of styrene derivatives

Spencer P. Pajk, Zisong Qi, Stephen J. Sujansky, Jeffrey S. Bandar

Chemical Science · 2022 · 11 citations · 62 references

DOIFull text

Open access

Concepts

Abstract

The base-catalyzed addition of 1-cyclopropylethanol to vinyl (hetero)arenes sequenced with an acidic reaction workup enables anti-Markovnikov hydration in a complementary fashion to traditional hydroboration/oxidation protocols.

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