Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?

Abstract

The search for new targets and drugs is a significant challenge worldwide, and TcCA is a potential candidate for developing new drugs. Several studied inhibitors were active against <i>Trypanosoma cruzi</i>, but their penetration and toxicity problems emerged. New approaches are in progress to obtain inhibitors with desired properties, allowing further steps such as tests using an adequate animal model and subsequent developments for the preclinical testing.