Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Abstract

CUR exerts a protective effect on the progression of PD by modulating the gut microbiota-metabolite axis. <i>Lactobacillaceae</i> and <i>Aerococcaceae</i>, along with key metabolites such as tyrosine and dopa play a dominant role in CUR-associated neuroprotection in PD mice. Our findings offer unique insights into the pathogenesis and potential treatment of PD.