Concepedia

Publication | Open Access

CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of <i>C9orf72</i> poly(PR) toxicity

DOIFull Paper Access

25

Citations

34

References

2022

Year

Wenting Guo, Haibo Wang, Arun Kumar Tharkeshwar, Julien Couthouis, Elke Braems, Pegah Masrori, Evelien Van Schoor, Yannan Fan, Karan Ahuja, Matthieu Moisse,
Alzheimer s & Dementia

Abstract

We identified NEK6, which regulates poly(PR)-mediated p53-related DNA damage, as a novel therapeutic target for C9orf72 FTD/ALS.

References

YearCitations

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