Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons

Sebastiaan Moonen, Marta J. Koper, Evelien Van Schoor, +6

Acta Neuropathologica

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineApoptosisCell Death +11

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

Marta J. Koper, Evelien Van Schoor, Simona Ospitalieri, +7

Acta Neuropathologica

Neurodegenerative DiseasesNeurobiology Of DiseaseAlzheimer's DiseaseNecrosome ComplexMedicine +10

Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

Sandra O. Tomé, Rik Vandenberghe, Simona Ospitalieri, +5

Acta Neuropathologica Communications

TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study

Donatienne Van Weehaeghe, Evelien Van Schoor, Joke De Vocht, +8

Journal of Nuclear Medicine

PathologySocial SciencesLogan PlotsNeuroinflammationInflammation +14

Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex

Evelien Van Schoor, Simona Ospitalieri, Sebastiaan Moonen, +8

Acta Neuropathologica

Pyroptosis ActivationMedicineWhite Matter MicrogliaWhite MatterAutophagy +10

Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

Lieselot Dedeene, Evelien Van Schoor, Rik Vandenberghe, +3

Acta Neuropathologica Communications

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

Marta J. Koper, Sandra O. Tomé, Klara Gawor, +12

Acta Neuropathologica Communications

Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases

Evelien Van Schoor, Marta J. Koper, Simona Ospitalieri, +10

Neuropathology and Applied Neurobiology

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, +8

Acta Neuropathologica Communications

CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of <i>C9orf72</i> poly(PR) toxicity

Wenting Guo, Haibo Wang, Arun Kumar Tharkeshwar, +27

Alzheimer s & Dementia