Recent advances in biosynthesis and pharmacology of β-elemene

High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera et al. · Nature · 2013 · 2.1K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Vincent J. J. Martin, Douglas J. Pitera, Sydnor T. Withers et al. · Nature Biotechnology · 2003 · 1.7K citations

Life Sciences, Biotechnology, Microbiology +14

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

Benedikt Engels, Pia Dahm, Stefan Jennewein · Metabolic Engineering · 2008 · 379 citations

Life Sciences, Biochemistry, Biotechnology +16

Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway inEscherichia coli enhances lycopene production

Seon-Won Kim, Jay D. Keasling · Biotechnology and Bioengineering · 2001 · 303 citations

Life Sciences, Biochemistry, Biotechnology +13

Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death

G. Wang, X. Li, Furong Huang et al. · Cellular and Molecular Life Sciences · 2005 · 242 citations · Full text

Medicine, Cancer Biology, Oncology +17